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Chemotherapy Drugs: Afatinib (Giotrif)

Afatinib (Giotrif)

Discover out what afatinib is, how you will have it and different necessary details about taking afatinib.

Afatinib (pronounced aff-a-tin-ib) is a cancer treatment drug and can also be identified by its model title Giotrif (pronounced jee-oh-triff).

It’s a treatment for lung cancer.

The way it works

Afatinib is a sort of cancer growth blocker referred to as a protein tyrosine kinase inhibitor (TKI). Tyrosine kinases are proteins that stimulate cells to develop. Afatinib blocks tyrosine kinases and in addition blocks epidermal growth issue receptor proteins in cancer cells. So afatinib can be referred to as an EGFR-TK inhibitor.

Your physician will verify your cancer cells to see if they’ve these receptors. Cancers which have these receptors are referred to as EGFR-TK constructive.

How you’ve got it

Afatinib is a pill. You swallow it entire with a glass of water.

You’ll be able to dissolve afatinib in a glass of nonetheless water if in case you have problem swallowing tablets. Don’t use some other kind of liquid. Drop the pill into the water with out crushing it. Stir it sometimes for as much as 15 minutes till the pill has damaged up into very small particles. Drink it right away. Fill the glass once more with water and drink it to be sure you take the entire dose.

When you could have it

You’re taking afatinib as soon as a day on an empty abdomen. You’re taking them a minimum of one hour earlier than consuming or three hours after consuming.

You normally keep it up taking it for so long as it’s nonetheless working, until the negative effects get too unhealthy.

You have to take tablets and capsules in line with the directions your physician or pharmacist provides you.

Whether or not you may have a full or empty abdomen can have an effect on how a lot of a drug will get into your bloodstream.

It is best to take the best dose, not kind of.

By no means cease taking a cancer drug with out speaking to your specialist first.

Exams throughout treatment

You have got blood exams earlier than beginning treatment and through your treatment. They test your ranges of blood cells and different substances within the blood. In addition they test how effectively your liver and kidneys are working.

Unwanted side effects

Necessary data

Different medicines, meals and drink

Cancer medicine can work together with another medicines and natural merchandise. Inform your physician or pharmacist about any medicines you take. This contains nutritional vitamins, natural dietary supplements and over-the-counter treatments.

Being pregnant and contraception

This drug could hurt a child growing within the womb. It’s important to not develop into pregnant or father a baby while you’re having treatment with this drug and for a minimum of a month afterwards.

Discuss to your physician or nurse about efficient contraception earlier than beginning treatment.

Fertility

We don’t understand how this treatment would possibly have an effect on fertility. You might not have the ability to turn out to be pregnant or father a baby after treatment with this drug. Speak to your physician earlier than beginning treatment if you happen to suppose you might wish to have a child sooner or later.

Some males would possibly be capable to retailer sperm earlier than beginning treatment. Some ladies may be capable of retailer eggs or embryos earlier than treatment.

 

Breastfeeding

Don’t breastfeed throughout this treatment as a result of the drug could come by in your breast milk.

Treatment for different circumstances

At all times inform different docs, nurses, pharmacists or dentists that you simply’re having this treatment when you want treatment for anything, together with tooth issues.

Immunisations

Don’t have immunisations with dwell vaccines when you’re having treatment and for a minimum of 6 months afterwards.

Within the UK, stay vaccines embrace rubella, mumps, measles, BCG, yellow fever and shingles vaccine (Zostavax).

You may:

  • produce other vaccines, however they may not offer you as a lot safety as traditional
  • have the flu vaccine
  • keep up a correspondence with different individuals who’ve had dwell vaccines as injections

Keep away from contact with individuals who’ve had stay vaccines taken by mouth (oral vaccines). This consists of the rotavirus vaccine given to infants. The virus is within the child’s urine for as much as 2 weeks and may make you unwell. So, keep away from altering their nappies for two weeks after their vaccination if potential. Or put on disposable gloves and wash your arms properly afterwards.

You additionally must keep away from anybody who has had oral polio or typhoid vaccination not too long ago.

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